The goals of this research were to assess the role of AMOC in global climate and identify the predictability of the associated climate impacts. Decadal prediction experiments were conducted as part of CMIP5 using a prototype GFDL-CM2.1 forecast system. The abrupt warming of the North Atlantic subpolar gyre (SPG), observed in the mid-1990s, was used as a case study to evaluate the forecast capabilities of the model, and to better understand the reasons for the observed changes.